How the ECS (endocannabinoid system) is involved in Genetic variations associated with CBD and autism

One of the genetic variations that are most common among those on the autism spectrum has to do with silencing of the FMR-1 gene; it’s still there, it just doesn’t get “turned on”.  

Scientists say CBD could help in several ways. First, it inhibits the CB1 receptor that endocannabinoids (eCBs) bind with, so even if there are too many eCBs, they won’t be able to have as much of an effect on reinforcement. Secondly, CBD binds to several proteins that could be thought of as the circuit breaker of our genetic code: they control what gets turned on and what doesn’t. The exact process of this activity is not yet well understood, but the administration of CBD in rats demonstrated elevated expression of this gene in cells that previously weren’t expressing it at all.

Research suggests CBD’s activity as a negative allosteric modulator at CB1 receptors could make up for the decreased number of receptors by further increasing the number of eCBs produced.

The most recent genetic discover related to autism, and perhaps the most important is the notable deficiency of the neuroligin-3gene in the brains of those with autism.

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